Adding Protein Context to the Human Protein-Protein Interaction Network to Reveal Meaningful Interactions
نویسندگان
چکیده
منابع مشابه
Adding Protein Context to the Human Protein-Protein Interaction Network to Reveal Meaningful Interactions
Interactions of proteins regulate signaling, catalysis, gene expression and many other cellular functions. Therefore, characterizing the entire human interactome is a key effort in current proteomics research. This challenge is complicated by the dynamic nature of protein-protein interactions (PPIs), which are conditional on the cellular context: both interacting proteins must be expressed in t...
متن کاملUsing the Protein-protein Interaction Network to Identifying the Biomarkers in Evolution of the Oocyte
Background Oocyte maturity includes nuclear and cytoplasmic maturity, both of which are important for embryo fertilization. The development of oocyte is not limited to the period of follicular growth, and starts from the embryonic period and continues throughout life. In this study, for the purpose of evaluating the effect of the FSH hormone on the expression of genes, GEO access codes for this...
متن کاملprotein-protein interaction network could reveal the relationship between the breast and colon cancer
aim: this study is aimed to elicit the possible correlation between breast and colon cancer from molecular prospectiveby analyzing and comparing pathway-based biomarkers.background: breast and colon cancer are known to be frequent causes of morbidity and mortality in men and womenaround the world. there is some evidence that while the incident of breast cancer in young women is high, it is repo...
متن کاملAdding 3D-Structural Context to Protein-Protein Interaction Data from High-Throughput Experiments
Abstract In the past decade, automatisation has led to an immense increase of data in biology. Next generation sequencing techniques will produce a vast amount of sequences across all species in the coming years. In many cases, identifying the function and biological role of a protein from its sequence can be a complicated and time-intensive task. The identification of a protein’s interaction p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2013
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1002860